Recombinant Human RAB27A, His-tagged
Cat.No. : | RAB27A-2479H |
Product Overview : | Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 27 kDa (241aa). |
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Cat. No. : | RAB27A-2479H |
Description : | Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2). |
Source : | E.coli. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol. |
Purity : | > 90% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C. |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name | RAB27A RAB27A, member RAS oncogene family [ Homo sapiens ] |
Synonyms | RAB27A, member RAS oncogene family; GS2; RAM; RAB27; HsT18676; MGC117246; RAB27A; ras-related protein Rab-27A; rab-27; GTP-binding protein Ram;Ras-related protein Rab-27A; Rab-27 |
Gene ID | 5873 |
mRNA Refseq | NM_004580 |
Protein Refseq | NP_004571 |
MIM | 603868 |
UniProt ID | P51159 |
Chromosome Location | 15q15-q21.1 |
Pathway | Diabetes pathways |
Function | GTP binding; GTPase activity; myosin V binding; nucleotide binding; protein binding |
Not For Human Consumption!
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