Recombinant Human RASA3 Protein, GST-tagged

• Cat.No.: RASA3-5906H
• Product Overview: Human RASA3 full-length ORF ( NP_031394.2, 1 a.a. - 834 a.a.) recombinant protein with GST-tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 122.1 kDa
• AA Sequence: MAVEDEGLRVFQSVKIKIGEAKNLP SYPGPSKMRDCYCTVNLDQEEVFRT KIVEKSLCPFYGEDFYCEIPRSFRH LSFYIFDRDVFRRDSIIGKVAIQKE DLQKYHNRDTWFQLQHVDADSEVQG KVHLELRLSEVITDTGVVCHKLATR IVECQGLPIVNGQCDPYATVTLAGP FRSEAKKTKVKRKTNNPQFDEVFYF EVTRPCSYSKKSHFDFEEEDVDKLE IRVDLWNASNLKFGDEFLGELRIPL KVLRQSSSYEAWYFLQPRDNGSKSL KPDDLGSLRLNVVYTEDHVFSSDYY SPLRDLLLKSADVEPVSASAAHILG EVCREKQEAAVPLVRLFLHYGRVVP FISAIASAEVKRTQDPNTIFRGNSL ASKCIDETMKLAGMHYLHVTLKPAI EEICQSHKPCEIDPVKLKDGENLEN NMENLRQYVDRVFHAITESGVSCPT VMCDIFFSLREAAAKRFQDDPDVRY TAVSSFIFLRFFAPAILSPNLFQLT PHHTDPQTSRTLTLISKTVQTLGSL SKSKSASFKESYMATFYEFFNEQKY ADAVKNFLDLISSSGRRDPKSVEQP IVLKEGFMIKRAQGRKRFGMKNFKK RWFRLTNHEFTYHKSKGDQPLYSIP IENILAVEKLEEESFKMKNMFQVIQ PERALYIQANNCVEAKDWIDILTKV SQCNQKRLTVYHPSAYLSGHWLCCR APSDSAPGCSPCTGGLPANIQLDID GDRETERIYSLFNLYMSKLEKMQEA CGSKSVYDGPEQEEYSTFVIDDPQE TYKTLKQVIAGVGALEQEHAQYKRD KFKKTKYGSQEHPIGDKSFQNYIRQ QSETSTHSI
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: RASA3 RAS p21 protein activator 3 [ Homo sapiens (human) ]
• Official Symbol: RASA3
• Synonyms: RASA3; RAS p21 protein activator 3; GAPIII; GAP1IP4BP; ras GTPase-activating protein 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; Ins(1,3,4,5)P4-binding protein; ins P4-binding protein
• Gene ID: 22821
• mRNA Refseq: NM_007368
• Protein Refseq: NP_031394
• MIM: 605182
• UniProt ID: Q14644