Recombinant Human RBFOX1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human RBFOX1 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : RBFOX1-853H
Product Overview : A2BP1 MS Standard C13 and N15-labeled recombinant protein (NP_061193) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 42.6 kDa
AA Sequence : MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP EYTGQTTVPE HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG QPQTQPSENT ENKSQPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF NERGSKGFGF VTFENSADAD RAREKLHGTV VEGRKIEVNN ATARVMTNKK TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM YSAPSSLVYT SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPYTRT RPLEQKLISE EDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : RBFOX1 RNA binding fox-1 homolog 1 [ Homo sapiens (human) ]
Official Symbol : RBFOX1
Synonyms : RBFOX1; RNA binding protein, fox-1 homolog (C. elegans) 1; RNA binding protein fox-1 homolog 1; A2BP1; ataxin 2 binding protein 1; FOX 1; hexaribonucleotide binding protein 1; HRNBP1; fox-1 homolog A; ataxin 2-binding protein 1; hexaribonucleotide-binding protein 1; 2BP1; FOX1; FOX-1;
Gene ID : 54715
mRNA Refseq : NM_018723
Protein Refseq : NP_061193
MIM : 605104
UniProt ID : Q9NWB1

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