| Description : |
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
128.3 kDa |
| AA Sequence : |
MPSGGDQSPPPPPPPPAAAASDEEE EDDGEAEDAAPPAESPTPQIQQRFD ELCSRLNMDEAARAEAWDSYRSMSE SYTLEGNDLHWLACALYVACRKSVP TVSKGTVEGNYVSLTRILKCSEQSL IEFFNKMKKWEDMANLPPHFRERTE RLERNFTVSAVIFKKYEPIFQDIFK YPQEEQPRQQRGRKQRRQPCTVSEI FHFCWVLFIYAKGNFPMISDDLVNS YHLLLCALDLVYGNALQCSNRKELV NPNFKGLSEDFHAKDSKPSSDPPCI IEKLCSLHDGLVLEAKGIKEHFWKP YIRKLYEKKLLKGKEENLTGFLEPG NFGESFKAINKAYEEYVLSVGNLDE RIFLGEDAEEEIGTLSRCLNAGSGT ETAERVQMKNILQQHFDKSKALRIS TPLTGVRYIKENSPCVTPVSTATHS LSRLHTMLTGLRNAPSEKLEQILRT CSRDPTQAIANRLKEMFEIYSQHFQ PDEDFSNCAKEIASKHFRFAEMLYY KVLESVIEQEQKRLGDMDLSGILEQ DAFHRSLLACCLEVVTFSYKPPGNF PFITEIFDVPLYHFYKVIEVFIRAE DGLCREVVKHLNQIEEQILDHLAWK PESPLWEKIRDNENRVPTCEEVMPP QNLERADEICIAGSPLTPRRVTEVR ADTGGLGRSITSPTTLYDRYSSPPA STTRRRLFVENDSPSDGGTPGRMPP QPLVNAVPVQNVSGETVSVTPVPGQ TLVTMATATVTANNGQTVTIPVQGI ANENGGITFFPVQVNVGGQAQAVTG SIQPLSAQALAGSLSSQQVTGTTLQ VPGQVAIQQISPGGQQQKQGQSVTS SSNRPRKTSSLSLFFRKVYHLAAVR LRDLCAKLDISDELRKKIWTCFEFS IIQCPELMMDRHLDQLLMCAIYVMA KVTKEDKSFQNIMRCYRTQPQARSQ VYRSVLIKGKRKRRNSGSSDSRSHQ NSPTELNKDRTSRDSSPVMRSSSTL PVPQPSSAPPTPTRLTGANSDMEEE ERGDLIQFYNNIYIKQIKTFAMKYS QANMDAPPLSPYPFVRTGSPRRIQL SQNHPVYISPHKNETMLSPREKIFY YFSNSPSKRLREINSMIHTGETPTK KRGILLEDGSESPAKRICPENHSAL LRRLQDVANDRGSHTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
