Recombinant Human RNF14 Protein, MYC/DDK-tagged

• Cat.No.: RNF14-686H
• Product Overview: Recombinant Human RNF14, transcript variant 4, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 53.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNF14 ring finger protein 14 [ Homo sapiens ]
• Official Symbol: RNF14
• Synonyms: RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; androgen receptor associated protein 54; androgen receptor-associated protein 54; HRIHFB2038; FLJ26004
• Gene ID: 9604
• mRNA Refseq: NM_183400
• Protein Refseq: NP_899647
• MIM: 605675
• UniProt ID: Q9UBS8