Recombinant Human RTKN Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human RTKN Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : RTKN-6216H
Product Overview : RTKN MS Standard C13 and N15-labeled recombinant protein (NP_149035) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 61.2 kDa
AA Sequence : MQDRLHILED LNMLYIRQMA LSLEDTELQR KLDHEIRMRE GACKLLAACS QREQALEATK SLLVCNSRIL SYMGELQRRK EAQVLGKTSR RPSDSGPPAE RSPCRGRVCI SDLRIPLMWK DTEYFKNKGD LHRWAVFLLL QLGEHIQDTE MILVDRTLTD ISFQSNVLFA EAGPDFELRL ELYGACVEEE GALTGGPKRL ATKLSSSLGR SSGRRVRASL DSAGGSGSSP ILLPTPVVGG PRYHLLAHTT LTLAAVQDGF RTHDLTLASH EENPAWLPLY GSVCCRLAAQ PLCMTQPTAS GTLRVQQAGE MQNWAQVHGV LKGTNLFCYR QPEDADTGEE PLLTIAVNKE TRVRAGELDQ ALGRPFTLSI SNQYGDDEVT HTLQTESREA LQSWMEALWQ LFFDMSQWKQ CCDEIMKIET PAPRKPPQAL AKQGSLYHEM AIEPLDDIAA VTDILTQREG ARLETPPPWL AMFTDQPALP NPCSPASVAP APDWTHPLPW GRPRTFSLDA VPPDHSPRAR SVAPLPPQRS PRTRGLCSKG QPRTWLQSPV TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : RTKN rhotekin [ Homo sapiens (human) ]
Official Symbol : RTKN
Synonyms : RTKN; rhotekin; rhotekin
Gene ID : 6242
mRNA Refseq : NM_033046
Protein Refseq : NP_149035
MIM : 602288
UniProt ID : Q9BST9

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