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Recombinant Human SETDB1 Protein (1-397 aa), GST-tagged

Cat.No. : SETDB1-2120H
Product Overview : Recombinant Human SETDB1 Protein (1-397 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length of Isoform 2.
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Description : Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing . The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Source : E. coli
Species : Human
Tag : GST
Form : Tris-based buffer,50% glycerol
Molecular Mass : 71.7 kDa
Protein length : 1-397 aa
AA Sequence : MSSLPGCIGLDAATATVESEEIAEL QQAVVEELGISMEELRHFIDEELEK MDCVQQRKKQLAELETWVIQKESEV AHVDQLFDDASRAVTNCESLVKDFY SKLGLQYRDSSSEDESSRPTEIIEI PDEDDDVLSIDSGDAGSRTPKDQKL REAMAALRKSAQDVQKFMDAVNKKS SSQDLHKGTLSQMSGELSKDGDLIV SMRILGKKRTKTWHKGTLIAIQTVG PGKKYKVKFDNKGKSLLSGNHIAYD YHPPADKLYVGSRVVAKYKDGNQVW LYAGIVAETPNVKNKLRFLIFFDDG YASYVTQSELYPICRPLKKTWEDIE DISCRDFIEEYVTAYPNRPMVLLKS GQLIKTEWEGTWWKSRVEEVDGSLV RILFLVLFFSTILEAEVGGGGT
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Gene Name : SETDB1 SET domain, bifurcated 1 [ Homo sapiens ]
Official Symbol : SETDB1
Synonyms : SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; H3-K9-HMTase4;
Gene ID : 9869
mRNA Refseq : NM_001145415
Protein Refseq : NP_001138887
MIM : 604396
UniProt ID : Q15047

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the treatments for SETDB1 recombinant protein? 11/24/2022

The current treatments for SETDB1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for chromatin modification.

If the level of SETDB1 recombinant protein is abnormal, what should I do? 10/27/2022

If the level of SETDB1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

What diseases is SETDB1 recombinant protein associated with? 12/16/2021

SETDB1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.

How can I detect the level of SETDB1 recombinant protein? 12/27/2020

The level of SETDB1 recombinant protein can be detected by gene sequencing and protein detection methods.

Does SETDB1 work in pregnant women? 10/03/2020

The level of SETDB1 recombinant protein in pregnant women may change due to the needs of fetal growth and development, and regular monitoring is required.

What is the association between SETDB1 recombinant protein and tumors? 04/14/2020

Some studies have shown that SETDB1 recombinant protein may be involved in the development and progression of tumors, especially in neurological tumors and lymphomas.

Customer Reviews (3)

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Reviews
04/12/2023

    SETDB1 has shown good biocompatibility and safety in related experiments.

    01/04/2023

      SETDB1 has good solubility and is easy to handle and purify.

      03/29/2022

        SETDB1 is consistent and reliable, with no significant differences between batches.

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