| Description : |
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
143 kDa |
| AA Sequence : |
MSSLPGCIGLDAATATVESEEIAEL QQAVVEELGISMEELRHFIDEELEK MDCVQQRKKQLAELETWVIQKESEV AHVDQLFDDASRAVTNCESLVKDFY SKLGLQYRDSSSEDESSRPTEIIEI PDEDDDVLSIDSGDAGSRTPKDQKL REAMAALRKSAQDVQKFMDAVNKKS SSQDLHKGTLSQMSGELSKDGDLIV SMRILGKKRTKTWHKGTLIAIQTVG PGKKYKVKFDNKGKSLLSGNHIAYD YHPPADKLYVGSRVVAKYKDGNQVW LYAGIVAETPNVKNKLRFLIFFDDG YASYVTQSELYPICRPLKKTWEDIE DISCRDFIEEYVTAYPNRPMVLLKS GQLIKTEWEGTWWKSRVEEVDGSLV RILFLDDKRCEWIYRGSTRLEPMFS MKTSSASALEKKQGQLRTRPNMGAV RSKGPVVQYTQDLTGTGTQFKPVEP PQPTAPPAPPFPPAPPLSPQAGDSD LESQLAQSRKQVAKKSTSFRPGSVG SGHSSPTSPALSENVSGGKPGINQT YRSPLGSTASAPAPSALPAPPAPPV FHGMLERAPAEPSYRAPMEKLFYLP HVCSYTCLSRVRPMRNEQYRGKNPL LVPLLYDFRRMTARRRVNRKMGFHV IYKTPCGLCLRTMQEIERYLFETGC DFLFLEMFCLDPYVLVDRKFQPYKP FYYILDITYGKEDVPLSCVNEIDTT PPPQVAYSKERIPGKGVFINTGPEF LVGCDCKDGCRDKSKCACHQLTIQA TACTPGGQINPNSGYQYKRLEECLP TGVYECNKRCKCDPNMCTNRLVQHG LQVRLQLFKTQNKGWGIRCLDDIAK GSFVCIYAGKILTDDFADKEGLEMG DEYFANLDHIESVENFKEGYESDAP CSSDSSGVDLKDQEDGNSGTEDPEE SNDDSSDDNFCKDEDFSTSSVWRSY ATRRQTRGQKENGLSETTSKDSHPP DLGPPHIPVPPSIPVGGCNPPSSEE TPKNKVASWLSCNSVSEGGFADSDS HSSFKTNEGGEGRAGGSRMEAEKAS TSGLGIKDEGDIKQAKKEDTDDRNK MSVVTESSRNYGYNPSPVKPEGLRR PPSKTSMHQSRRLMASAQSNPDDVL TLSSSTESEGESGTSRKPTAGQTSA TAVDSDDIQTISSGSEGDDFEDKKN MTGPMKRQVAVKSTRGFALKSTHGI AIKSTNMASVDKGESAPVRKNTRQF YDGEESCYIIDAKLEGNLGRYLNHS CSPNLFVQNVFVDTHDLRFPWVAFF ASKRIRAGTELTWDYNYEVGSVEGK ELLCCCGAIECRGRLLTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
