Recombinant Human SETDB1 Protein (510-1290, end), N His-FLAG tagged

• Cat.No.: SETDB1-12H
• Product Overview: Human SetDB1 (variant 2), also known as Histone-lysine Nmethyltransferase SETDB1, SET domain bifurcated 1, KMT1E, ERG-associated protein with SET domain (ESET), GenBank Accession No. NM_012432, a.a. 510-1290(end) expressed in a Baculovirus Sf9 cell expression system.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST&His
• Protein Length: 510-1290, end
• Description: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
• Form: Aqueous buffer solution
• Molecular Mass: 114 kDa
• Purity: ≥85%
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Usage: Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
• Storage: At least 6 months at -80 centigrade.
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% Glycerol and variable glutathione
• Shipping: At -80 centigrade
• Warning: Avoid freeze/thaw cycles

Gene Information

• Gene Name: SETDB1 SET domain, bifurcated 1 [ Homo sapiens (human) ]
• Official Symbol: SETDB1
• Synonyms: SETDB1; SET domain, bifurcated 1; histone-lysine N-methyltransferase SETDB1; ESET; KG1T; KIAA0067; KMT1E; H3-K9-HMTase 4; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with a SET domain, ESET; histone-lysine N-methyltransferase, H3lysine-9 specific 4; H3-K9-HMTase4
• Gene ID: 9869
• mRNA Refseq: NM_012432
• Protein Refseq: NP_036564
• MIM: 604396
• UniProt ID: Q15047