| Description : |
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63 kDa |
| AA Sequence : |
MNGPALQPSSPSSAPSASPAAAPRG WSEFCELHAVAAARELARQYWLFAR EHPQHAPLRAELVSLQFTDLFQRYF CREVRDGRAPGRDYRDTGRGPPAKA EASPEPGPGPAAPGLPKARSSEELA PPRPPGPCSFQHFRRSLRHIFRRRS AGELPAAHTAAAPGTPGEAAETPAR PGLAKKFLPWSLAREPPPEALKEAV LRYSLADEASMDSGARWQRGRLALR RAPGPDGPDRVLELFDPPKSSRPKL QAACSSIQEVRRCTRLEMPDNLYTF VLKVKDRTDIIFEVGDEQQLNSWMA ELSECTGRGLESTEAEMHIPSALEP STSSSPRGSTDSLNQGASPGGLLDP ACQKTDHFLSCYPWFHGPISRVKAA QLVQLQGPDAHGVFLVRQSETRRGE YVLTFNFQGIAKHLRLSLTERGQCR VQHLHFPSVVDMLHHFQRSPIPLEC GAACDVRLSSYVVVVSQPPGSCNTV LFPFSLPHWDSESLPHWGSELGLPH LSSSGCPRGLSPEGLPGRSSPPEQI FHLVPSPEELANSLQHLEHEPVNRA RDSDYEMDSSSRSHLRAIDNQYTPL TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
