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Recombinant Human SH2D1A Protein, MYC/DDK-tagged

Cat.No. : SH2D1A-22H
Product Overview : Recombinant protein of human SH2 domain protein 1A (SH2D1A), transcript variant 1 with a C-Myc/DDK tag was expressed in HEK293T.
  • Specification
  • Gene Information
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Description : This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 14 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Gene Name : SH2D1A SH2 domain containing 1A [ Homo sapiens (human) ]
Official Symbol : SH2D1A
Synonyms : SH2D1A; SH2 domain containing 1A; LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A; SH2 domain-containing protein 1A; Duncan disease SH2-protein; LAM associated protein/SH2 domain protein 1A; SLAM-associated protein; T cell signal transduction molecule SAP; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein
Gene ID : 4068
mRNA Refseq : NM_002351
Protein Refseq : NP_002342
MIM : 300490
UniProt ID : O60880

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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