Recombinant Human SH2D1A Protein, MYC/DDK-tagged


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Recombinant Human SH2D1A Protein, MYC/DDK-tagged

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Cat.No. : SH2D1A-22H
Product Overview : Recombinant protein of human SH2 domain protein 1A (SH2D1A), transcript variant 1 with a C-Myc/DDK tag was expressed in HEK293T.
Description : This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 14 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Figure :

Gene Name : SH2D1A SH2 domain containing 1A [ Homo sapiens (human) ]
Official Symbol : SH2D1A
Synonyms : SH2D1A; SH2 domain containing 1A; LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A; SH2 domain-containing protein 1A; Duncan disease SH2-protein; LAM associated protein/SH2 domain protein 1A; SLAM-associated protein; T cell signal transduction molecule SAP; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein
Gene ID : 4068
mRNA Refseq : NM_002351
Protein Refseq : NP_002342
MIM : 300490
UniProt ID : O60880

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