Recombinant Human SHANK3 Protein, His&ABP tagged

• Cat.No.: SHANK3-10H
• Product Overview: Recombinant Human SHANK3 Protein with His&ABP tag was expressed in E.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: ABP&His
• Protein Length: 1088-1191 aa
• Description: SHANK3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. It interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. SHANK3 plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, SHANK3 participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. It also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. SHANK3 may be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
• Form: Liquid
• AASequence: PSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREERKSPEDK
• Application: Ctrl; BLOCK
• Purity: > 80% by SDS-PAGE and Coomassie blue staining
• Storage: At -20 centigrade, Avoid Freeze/Thaw Cycles
• Storage Buffer: PBS/1M urea, pH 7.4
• Concentration: ≥5.0 mg/mL
• Shipping: Wet ice

Gene Information

• Gene Name: SHANK3 SH3 and multiple ankyrin repeat domains 3 [ Homo sapiens (human) ]
• Official Symbol: SHANK3
• Synonyms: SHANK3; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 3; KIAA1650; proline rich synapse associated protein 2; prosap2; PSAP2; shank postsynaptic density protein; SPANK 2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3
• Gene ID: 85358
• mRNA Refseq: NM_033517
• Protein Refseq: NP_277052
• MIM: 606230
• UniProt ID: Q9BYB0