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Recombinant Human SHC1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SHC1-1005H
Product Overview : SHC1 MS Standard C13 and N15-labeled recombinant protein (NP_003020) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 51.7 kDa
AA Sequence : MNKLSGGGGRRTRVEGGQLGGEEWT RHGSFVNKPTRGWLHPNDKVMGPGV SYLVRYMGCVEVLQSMRALDFNTRT QVTREAISLVCEAVPGAKGATRRRK PCSRPLSSILGRSNLKFAGMPITLT VSTSSLNLMAADCKQIIANHHMQSI SFASGGDPDTAEYVAYVAKDPVNQR ACHILECPEGLAQDVISTIGQAFEL RFKQYLRNPPKLVTPHDRMAGFDGS AWDEEEEEPPDHQYYNDFPGKEPPL GGVVDMRLREGAAPGAARPTAPNAQ TPSHLGATLPVGQPVGGDPEVRKQM PPPPPCPAGRELFDDPSYVNVQNLD KARQAVGGAGPPNPAINGSAPRDLF DMKPFEDALRVPPPPQSVSMAEQLR GEPWFHGKLSRREAEALLQLNGDFL VRESTTTPGQYVLTGLQSGQPKHLL LVDPEGVVRTKDHRFESVSHLISYH MDNHLPIISAGSELCLQQPVERKLT RTRPLEQKLISEEDLAANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : SHC1 SHC adaptor protein 1 [ Homo sapiens (human) ]
Official Symbol : SHC1
Synonyms : SHC1; SHC (Src homology 2 domain containing) transforming protein 1; SHC, SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1; p66; SH2 domain protein C1; SHC-transforming protein 3; SHC-transforming protein A; SHC (Src homology 2 domain-containing) transforming protein 1; SHC; SHCA; FLJ26504;
Gene ID : 6464
mRNA Refseq : NM_003029
Protein Refseq : NP_003020
MIM : 600560
UniProt ID : P29353

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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