Recombinant Human SIGLEC10 protein, Fc-Avi-tagged

• Cat.No.: SIGLEC10-967H
• Product Overview: Human siglec 10 Protein is expressed from mammalian with Fc and Avi Tag at the C-terminal. It contains Met17-Thr546.

Specification

• Description: Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are Itype lectins that belong to the immunoglobulin superfamily. They are characterized by an Nterminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
• Source: HEK293
• Species: Human
• Tag: Fc-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 85.8KDa. Due to glycosylation, the protein migrates to 95- 110KDa based on Bis-Tris PAGE result.
• Protein length: Met17-Thr546
• Endotoxin: Less than 0.01EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: SIGLEC10 sialic acid binding Ig like lectin 10 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC10
• Synonyms: siglec 10; siglec-10; siglec10; Sialic acid-binding Ig-like lectin 10; Siglec-like protein 2; SLG2
• Gene ID: 89790
• mRNA Refseq: NM_001171156.2
• Protein Refseq: NP_001164627.1
• MIM: 606091
• UniProt ID: Q96LC7