Recombinant Human Sin3A-associated Protein, 18kDa

• Cat.No.: SAP18-182H
• Product Overview: Recombinant SAP18 protein was expressed inE.coliand purified by using conventional chromatography techniques. MW =19.7 kDa (173 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl,
• Purity: > 90% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method ).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SAP18 Sin3A-associated protein, 18kDa [ Homo sapiens ]
• Synonyms: SAP18; Sin3A-associated protein, 18kDa; SAP18P; 2HOR0202; MGC27131; sin3-associated polypeptide, p18; cell growth inhibiting protein 38; histone deacetlyase complex subunit SAP18; sin3A-associated protein, 18kDa; SAP18p; Histone deacetylase complex subunit SAP18; Sin3-associated polypeptide, 18 kDa; Sin3-associated polypeptide p18; Cell growth-inhibiting protein 38; GIG38; OTTHUMP00000018107
• Gene ID: 10284
• mRNA Refseq: NM_005870
• Protein Refseq: NP_005861
• MIM: 602949
• UniProt ID: O00422
• Chromosome Location: 13q12.11
• Function: protein binding; transcription corepressor activity