Description : |
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. |
Source : |
CHO |
Species : |
Human |
Tag : |
Fc |
Form : |
Lyophilized |
Molecular Mass : |
63.5 kDa |
Protein Length : |
504 |
AA Sequence : |
MEPAGPAPGRLGPLLCLLLAASCAW SGVAGEEELQVIQPDKSVLVAAGET ATLRCTATSLIPVGPIQWFRGAGPG RELIYNQKEGHFPRVTTVSDLTKRN NMDFSIRIGNITPADAGTYYCVKFR KGSPDDVEFKSGAGTELSVRAKPSA PVVSGPAARATPQHTVSFTCESHGF SPRDITLKWFKNGNELSDFQTNVDP VGESVSYSIHSTAKVVLTREDVHSQ VICEVAHVTLQGDPLRGTANLSETI RVPPTLEVTQQPVRAENQVNVTCQV RKFYPQRLQLTWLENGNVSRTETAS TVTENKDGTYNWMSWLLVNVSAHRD DVKLTCQVEHDGQPAVSKSHDLKVS AHPKEQGSNTAAENTGSNERNIYIV VGVVCTLLVALLMAALYLVRIRQKK AQGSTSSTRLHEPEKNAREITQDTN DITYADLNLPKGKKPAPQAAEPNNH TEYASIQTSPQPASEDTLTYADLDM VHLNRTPKQPAPKPEPSFSEYASVQ VPRK |
Purity : |
> 98% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
At -20 centigrade. |
Concentration : |
1 mg/mL |
Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |