Active Recombinant Human SIRT6 Protein, GST-tagged
Cat.No. : | SIRT6-28517H |
Product Overview : | Human Sirtuin 6 (GenBank Accession No. NM_016539), full length with N-terminal GST-tag was expressed in an E. coli expression system. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | Aqueous buffer solution |
Bio-activity : | 1.5 pmol/min/µg Assay Conditions: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 µM BPS SIRT6 substrate 2, 500 µM NAD+ and Sirtuin 6 (18 – 2000 ng). Incubation condition: 60 min at 37ºC followed by developing for 15 min at room temperature. |
Molecular Mass : | 65 kDa |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. |
Storage Buffer : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | SIRT6 sirtuin 6 [ Homo sapiens (human) ] |
Official Symbol : | SIRT6 |
Synonyms : | SIRT6; sirtuin 6; SIR2L6; NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6; EC 2.4.2.31 |
Gene ID : | 51548 |
mRNA Refseq : | NM_016539 |
Protein Refseq : | NP_057623 |
MIM : | 606211 |
UniProt ID : | Q8N6T7 |
Products Types
◆ Recombinant Protein | ||
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SIRT6-121H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-2691H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-24H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-28517TH | Recombinant Human SIRT6, T7 -tagged | +Inquiry |
◆ Lysates | ||
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionSIRT6 can participate in the DNA repair process by influencing the activity of DNA repair enzymes through deacetylation modification.
This proteinexpression of genes related to fat metabolism through deacetylation modifications.
Yes, SIRT6 has therapeutic potential. In tumor therapy, drug activation or gene therapy targeting SIRT6 may become a new avenue for treating tumors. At the same time, activators for SIRT6 are also being developed.
SIRT6 regulates the expression of specific genes through deacetylation, which in turn affects nutrient metabolism and energy balance. For example, in adipocytes, activation of SIRT6 may lead to abnormal expression of genes related to adipopocyte, which in turn affects processes such as differentiation, proliferation, and apoptosis of adipocytes.
Deletion of SIRT6 may lead to cell growth arrest, increased apoptosis, and genomic instability.
There are differences in the expression levels of SIRT6 in different tissues and cells. For example, in tissues and cells such as the reproductive system, nervous system, and immune system, there may be varying degrees of variation in the expression levels of SIRT6.
Customer Reviews (3)
Write a reviewThis protein has high yield and good economic benefits.
Laboratory staff feedback that the protein is easy to operate, can meet the needs of the experiment, and has a good cost performance.
SIRT6 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.
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