Recombinant Human SLC6A3 protein, GST-tagged

• Cat.No.: SLC6A3-2743H
• Product Overview: Recombinant Human SLC6A3(1 a.a. - 620 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 94.9 kDa
• AA Sequence: MSKSKCSVGLMSSVVAPAKEPNAVG PKEVELILVKEQNGVQLTSSTLTNP RQSPVEAQDRETWGKKIDFLLSVIG FAVDLANVWRFPYLCYKNGGGAFLV PYLLFMVIAGMPLFYMELALGQFNR EGAAGVWKICPILKGVGFTVILISL YVGFFYNVIIAWALHYLFSSFTTEL PWIHCNNSWNSPNCSDAHPGDSSGD SSGLNDTFGTTPAAEYFERGVLHLH QSHGIDDLGPPRWQLTACLVLVIVL LYFSLWKGVKTSGKVVWITATMPYV VLTALLLRGVTLPGAIDGIRAYLSV DFYRLCEASVWIDAATQVCFSLGVG FGVLIAFSSYNKFTNNCYRDAIVTT SINSLTSFSSGFVVFSFLGYMAQKH SVPIGDVAKDGPGLIFIIYPEAIAT LPLSSAWAVVFFIMLLTLGIDSAMG GMESVITGLIDEFQLLHRHRELFTL FIVLATFLLSLFCVTNGGIYVFTLL DHFAAGTSILFGVLIEAIGVAWFYG VGQFSDDIQQMTGQRPSLYWRLCWK LVSPCFLLFVVVVSIVTFRPPHYGA YIFPDWANALGWVIATSSMAMVPIY AAYKFCSLPGSFREKLAYAIAPEKD RELVDRGEVRQFTLRHWLKV
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 [ Homo sapiens ]
• Official Symbol: SLC6A3
• Synonyms: SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; DAT1; sodium-dependent dopamine transporter; DAT; dopamine transporter; DA transporter; solute carrier family 6 member 3
• Gene ID: 6531
• mRNA Refseq: NM_001044
• Protein Refseq: NP_001035
• MIM: 126455
• UniProt ID: Q01959
• Chromosome Location: 5p15.3
• Pathway: Alpha-synuclein signaling, organism-specific biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopamine clearance from the synaptic cleft, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem
• Function: dopamine binding; dopamine transmembrane transporter activity; dopamine:sodium symporter activity; drug binding; monoamine transmembrane transporter activity; protein N-terminus binding; protein complex binding; receptor binding; symporter activity