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Recombinant Human SMARCC1 Protein (449-669 aa), His-SUMO-tagged

Cat.No. : SMARCC1-1068H
Product Overview : Recombinant Human SMARCC1 Protein (449-669 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.
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Description : Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 41.4 kDa
Protein length : 449-669 aa
AA Sequence : IIIPSYASWFDYNCIHVIERRALPE FFNGKNKSKTPEIYLAYRNFMIDTY RLNPQEYLTSTACRRNLTGDVCAVM RVHAFLEQWGLVNYQVDPESRPMAM GPPPTPHFNVLADTPSGLVPLHLRS PQVPAAQQMLNFPEKNKEKPVDLQN FGLRTDIYSKKTLAKSKGASAGREW TEQETLLLLEALEMYKDDWNKVSEH VGSRTQDECILHFLRLPIEDP
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Homo sapiens ]
Official Symbol : SMARCC1
Synonyms : SMARCC1; BAF155; CRACC1; Rsc8; SRG3; SWI3;
Gene ID : 6599
mRNA Refseq : NM_003074
Protein Refseq : NP_003065
MIM : 601732
UniProt ID : Q92922

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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