Recombinant Human SMARCC1 Protein (449-669 aa), His-SUMO-tagged

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Recombinant Human SMARCC1 Protein (449-669 aa), His-SUMO-tagged

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Cat.No. : SMARCC1-1068H
Product Overview : Recombinant Human SMARCC1 Protein (449-669 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.
Description : Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Source : E. coli
Species : Human
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 41.4 kDa
Protein length : 449-669 aa
AA Sequence : IIIPSYASWF DYNCIHVIER RALPEFFNGK NKSKTPEIYL AYRNFMIDTY RLNPQEYLTS TACRRNLTGD VCAVMRVHAF LEQWGLVNYQ VDPESRPMAM GPPPTPHFNV LADTPSGLVP LHLRSPQVPA AQQMLNFPEK NKEKPVDLQN FGLRTDIYSK KTLAKSKGAS AGREWTEQET LLLLEALEMY KDDWNKVSEH VGSRTQDECI LHFLRLPIED P
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Homo sapiens ]
Official Symbol : SMARCC1
Synonyms : SMARCC1; BAF155; CRACC1; Rsc8; SRG3; SWI3;
Gene ID : 6599
mRNA Refseq : NM_003074
Protein Refseq : NP_003065
MIM : 601732
UniProt ID : Q92922

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