Active Recombinant Human SNCA protein
Cat.No. : | SNCA-240H |
Product Overview : | Recombinant Human SNCA was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | alpha -Synuclein is a member of a family of small, soluble proteins that also include beta -, and gamma -Synuclein. alpha -Synuclein is predominantly expressed in neurons of the central nervous system, specifically in the presynaptic region of nerve terminals. This protein cycles between a free, partially unfolded form and a helical, membrane-bound form. alpha -Synuclein can aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms are major components of Lewy Bodies and have been linked to the pathogenesis of Parkinson's disease dementia. alpha -Synuclein aggregates can also be found associated with amyloid plaques in Alzheimer's disease. |
Source : | E. coli |
Species : | Human |
Form : | X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 1 mM DTT |
Bio-activity : | Recombinant Human alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP/Stub1. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human alpha -Synuclein concentration of 0.5-2.5 μM. |
Molecular Mass : | Predicted Molecular Mass: 14 kDa |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 centigrade as supplied. 6 months, -70 centigrade under sterile conditions after opening. |
Gene Name : | SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ] |
Official Symbol : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; synuclein alpha-140; non A-beta component of AD amyloid; PARK1; PARK4; MGC110988; |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345 |
Protein Refseq : | NP_000336 |
MIM : | 163890 |
UniProt ID : | P37840 |
Products Types
◆ Recombinant Protein | ||
SNCA-01H | Active Recombinant Human SNCA Protein | +Inquiry |
SNCA-8524M | Recombinant Mouse SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
Snca-5996M | Recombinant Mouse Snca Protein, Myc/DDK-tagged | +Inquiry |
Snca-1372R | Recombinant Rat Snca Protein, GST-tagged | +Inquiry |
SNCA-2055H | Recombinant Human SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
SNCA-27339TH | Native Human SNCA | +Inquiry |
SNCA-27342TH | Native Human SNCA | +Inquiry |
SNCA-27341TH | Native Human SNCA | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
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