Recombinant Human SNCA Protein, MYC/DDK-tagged

• Cat.No.: SNCA-2058H
• Product Overview: Recombinant human SNCA protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293

Specification

• Description: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. [UniProtKB/Swiss-Prot Function]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 14.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ]
• Official Symbol: SNCA
• Synonyms: NACP; PARK1; PARK4; PD1
• Gene ID: 6622
• mRNA Refseq: NM_000345
• Protein Refseq: NP_000336
• MIM: 163890
• UniProt ID: P37840

Reviews

08/31/2020

Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

03/12/2020

Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.

10/16/2017

In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

Q&As

Can SNCA protein levels in cerebrospinal fluid be used as a diagnostic marker for Parkinson's disease?

Yes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.

What potential therapeutic strategies target SNCA protein for Parkinson's disease treatment?

Therapies may include reducing SNCA aggregation or preventing its misfolding.

Are there any genetic mutations related to SNCA protein that increase the risk of Parkinson's disease?

Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.

How is SNCA protein associated with neurodegenerative diseases?

Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.

Are there any ongoing clinical trials investigating SNCA-related therapies?

Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.