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Recombinant Human SNCB Protein, MYC/DDK-tagged

Cat.No. : SNCB-245H
Product Overview : Recombinant protein of human synuclein, beta (SNCB), transcript variant 1 with MYC/DDK at C-terminal was expressed in HEK293T.
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  • Gene Information
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Description : Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Source : HEK293
Species : Human
Tag : MYC/DDK
Molecular Mass : 14.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at –80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : SNCB
Official Symbol : SNCB synuclein beta [ Homo sapiens (human) ]
Synonyms : SNCB; synuclein beta; beta-synuclein; I(2)-synuclein
Gene ID : 6620
mRNA Refseq : NM_003085
Protein Refseq : NP_003076
MIM : 602569
UniProt ID : Q16143

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic mutations associated with SNCB protein that contribute to neurodegenerative diseases? 03/27/2021

Mutations in the SNCB gene have been identified in certain cases of familial Parkinson's disease, suggesting a genetic link to the disease.

Are there any imaging techniques that can visualize SNCB protein aggregates in the brain? 01/12/2021

Positron emission tomography (PET) imaging using specific radiotracers has shown promise in visualizing SNCB protein aggregates in the brain.

How does SNCB protein interact with other proteins in the brain? 05/13/2018

SNCB protein has been found to interact with alpha-synuclein and other proteins in the brain, potentially influencing disease pathogenesis.

What are the future directions for research on the clinical application of SNCB protein? 03/02/2017

Future research directions include further validation of SNCB protein as a biomarker, development of targeted therapeutic interventions, and understanding the molecular mechanisms underlying its role in neurodegenerative diseases.

How do fluctuations in SNCB protein levels correlate with disease progression in neurodegenerative diseases? 01/22/2016

Studies have suggested that alterations in SNCB protein levels may correlate with disease severity and progression in neurodegenerative diseases.

Customer Reviews (3)

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Reviews
01/30/2019

    Highly recommended!

    06/22/2018

      The SNCB protein is undoubtedly a superior choice, boasting extraordinary quality that guarantees it will fulfill all my experimental requirements.

      11/14/2016

        Their team of experts is highly knowledgeable, responsive, and dedicated to providing prompt solutions to any challenges I may face.

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