| Description : |
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
285 kDa |
| AA Sequence : |
MDPSGVKVLETAEDIQERRQQVLDR YHRFKELSTLRRQKLEDSYRFQFFQ RDAEELEKWIQEKLQIASDENYKDP TNLQGKLQKHQAFEAEVQANSGAIV KLDETGNLMISEGHFASETIRTRLM ELHRQWELLLEKMREKGIKLLQAQK LVQYLRECEDVMDWINDKEAIVTSE ELGQDLEHVEVLQKKFEEFQTDMAA HEERVNEVNQFAAKLIQEQHPEEEL IKTKQDEVNAAWQRLKGLALQRQGK LFGAAEVQRFNRDVDETISWIKEKE QLMASDDFGRDLASVQALLRKHEGL ERDLAALEDKVKALCAEADRLQQSH PLSATQIQVKREELITNWEQIRTLA AERHARLNDSYRLQRFLADFRDLTS WVTEMKALINADELASDVAGAEALL DRHQEHKGEIDAHEDSFKSADESGQ ALLAAGHYASDEVREKLTVLSEERA ALLELWELRRQQYEQCMDLQLFYRD TEQVDNWMSKQEAFLLNEDLGDSLD SVEALLKKHEDFEKSLSAQEEKITA LDEFATKLIQNNHYAMEDVATRRDA LLSRRNALHERAMRRRAQLADSFHL QQFFRDSDELKSWVNEKMKTATDEA YKDPSNLQGKVQKHQAFEAELSANQ SRIDALEKAGQKLIDVNHYAKDEVA ARMNEVISLWKKLLEATELKGIKLR EANQQQQFNRNVEDIELWLYEVEGH LASDDYGKDLTNVQNLQKKHALLEA DVAAHQDRIDGITIQARQFQDAGHF DAENIKKKQEALVARYEALKEPMVA RKQKLADSLRLQQLFRDVEDEETWI REKEPIAASTNRGKDLIGVQNLLKK HQALQAEIAGHEPRIKAVTQKGNAM VEEGHFAAEDVKAKLHELNQKWEAL KAKASQRRQDLEDSLQAQQYFADAN EAESWMREKEPIVGSTDYGKDEDSA EALLKKHEALMSDLSAYGSSIQALR EQAQSCRQQVAPTDDETGKELVLAL YDYQEKSPREVTMKKGDILTLLNST NKDWWKVEVNDRQGFVPAAYVKKLD PAQSASRENLLEEQGSIALRQEQID NQTRITKEAGSVSLRMKQVEELYHS LLELGEKRKGMLEKSCKKFMLFREA NELQQWINEKEAALTSEEVGADLEQ VEVLQKKFDDFQKDLKANESRLKDI NKVAEDLESEGLMAEEVQAVQQQEV YGMMPRDETDSKTASPWKSARLMVH TVATFNSIKELNERWRSLQQLAEER SQLLGSAHEVQRFHRDADETKEWIE EKNQALNTDNYGHDLASVQALQRKH EGFERDLAALGDKVNSLGETAERLI QSHPESAEDLQEKCTELNQAWSSLG KRADQRKAKLGDSHDLQRFLSDFRD LMSWINGIRGLVSSDELAKDVTGAE ALLERHQEHRTEIDARAGTFQAFEQ FGQQLLAHGHYASPEIKQKLDILDQ ERADLEKAWVQRRMMLDQCLELQLF HRDCEQAENWMAAREAFLNTEDKGD SLDSVEALIKKHEDFDKAINVQEEK IAALQAFADQLIAAGHYAKGDISSR RNEVLDRWRRLKAQMIEKRSKLGES QTLQQFSRDVDEIEAWISEKLQTAS DESYKDPTNIQSKHQKHQAFEAELH ANADRIRGVIDMGNSLIERGACAGS EDAVKARLAALADQWQFLVQKSAEK SQKLKEANKQQNFNTGIKDFDFWLS EVEALLASEDYGKDLASVNNLLKKH QLLEADISAHEDRLKDLNSQADSLM TSSAFDTSQVKDKRDTINGRFQKIK SMAASRRAKLNESHRLHQFFRDMDD EESWIKEKKLLVGSEDYGRDLTGVQ NLRKKHKRLEAELAAHEPAIQGVLD TGKKLSDDNTIGKEEIQQRLAQFVE HWKELKQLAAARGQRLEESLEYQQF VANVEEEEAWINEKMTLVASEDYGD TLAAIQGLLKKHEAFETDFTVHKDR VNDVCTNGQDLIKKNNHHEENISSK MKGLNGKVSDLEKAAAQRKAKLDEN SAFLQFNWKADVVESWIGEKENSLK TDDYGRDLSSVQTLLTKQETFDAGL QAFQQEGIANITALKDQLLAAKHVQ SKAIEARHASLMKRWSQLLANSAAR KKKLLEAQSHFRKVEDLFLTFAKKA SAFNSWFENAEEDLTDPVRCNSLEE IKALREAHDAFRSSLSSAQADFNQL AELDRQIKSFRVASNPYTWFTMEAL EETWRNLQKIIKERELELQKEQRRQ EENDKLRQEFAQHANAFHQWIQETR TYLLDGSCMVEESGTLESQLEATKR KHQEIRAMRSQLKKIEDLGAAMEEA LILDNKYTEHSTVGLAQQWDQLDQL GMRMQHNLEQQIQARNTTGVTEEAL KEFSMMFKHFDKDKSGRLNHQEFKS CLRSLGYDLPMVEEGEPDPEFEAIL DTVDPNRDGHVSLQEYMAFMISRET ENVKSSEEIESAFRALSSEGKPYVT KEELYQNLTREQADYCVSHMKPYVD GKGRELPTAFDYVEFTRSLFVNTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
