Recombinant Human STAMBPL1 Protein (D2-R436), His tagged

• Cat.No.: STAMBPL1-1351S
• Product Overview: Recombinant Human 6His-TEV-GG-AMSH(S2-R424 end) Protein was expressed in E. coli.

Specification

• Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: D2-R436
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]
• Official Symbol: STAMBPL1
• Synonyms: STAMBPL1; STAM binding protein like 1; AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2; AMSH-like protease; associated molecule with the SH3 domain of STAM (AMSH) - Family Protein; associated molecule with the SH3 domain of STAM (AMSH) like protein; EC 3.1.2.15
• Gene ID: 57559
• mRNA Refseq: NM_020799
• Protein Refseq: NP_065850
• MIM: 612352
• UniProt ID: Q96FJ0