Recombinant Human STAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: STAP1-5721H
• Product Overview: STAP1 MS Standard C13 and N15-labeled recombinant protein (NP_036240) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 34.3 kDa
• AA Sequence: MMAKKPPKPAPRRIFQERLKITALP LYFEGFLLIKRSGYREYEHYWTELR GTTLFFYTDKKSIIYVDKLDIVDLT CLTEQNSTEKNCAKFTLVLPKEEVQ LKTENTESGEEWRGFILTVTELSVP QNVSLLPGQVIKLHEVLEREKKRRI ETEQSTSVEKEKEPTEDYVDVLNPM PACFYTVSRKEATEMLQKNPSLGNM ILRPGSDSRNYSITIRQEIDIPRIK HYKVMSVGQNYTIELEKPVTLPNLF SVIDYFVKETRGNLRPFICSTDENT GQEPSMEGRSEKLKKNPHIATRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: STAP1 signal transducing adaptor family member 1 [ Homo sapiens (human) ]
• Official Symbol: STAP1
• Synonyms: STAP1; signal transducing adaptor family member 1; signal-transducing adaptor protein 1; BCR downstream signaling 1; BRDG1; STAP 1; docking protein BRDG1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein-1; STAP-1
• Gene ID: 26228
• mRNA Refseq: NM_012108
• Protein Refseq: NP_036240
• MIM: 604298
• UniProt ID: Q9ULZ2