Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | STAT3-951H |
Product Overview : | STAT3 MS Standard C13 and N15-labeled recombinant protein (NP_998827) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 82.9 kDa |
AA Sequence : | MAQWNQLQQLDTRYLEQLHQLYSDS FPMELRQFLAPWIESQDWAYAASKE SHATLVFHNLLGEIDQQYSRFLQES NVLYQHNLRRIKQFLQSRYLEKPME IARIVARCLWEESRLLQTAATAAQQ GGQANHPTAAVVTEKQQMLEQHLQD VRKRVQDLEQKMKVVENLQDDFDFN YKTLKSQGDMQDLNGNNQSVTRQKM QQLEQMLTALDQMRRSIVSELAGLL SAMEYVQKTLTDEELADWKRRQQIA CIGGPPNICLDRLENWITSLAESQL QTRQQIKKLEELQQKVSYKGDPIVQ HRPMLEERIVELFRNLMKSAFVVER QPCMPMHPDRPLVIKTGVQFTTKVR LLVKFPELNYQLKIKVCIDKDSGDV AALRGSRKFNILGTNTKVMNMEESN NGSLSAEFKHLTLREQRCGNGGRAN CDASLIVTEELHLITFETEVYHQGL KIDLETHSLPVVVISNICQMPNAWA SILWYNMLTNNPKNVNFFTKPPIGT WDQVAEVLSWQFSSTTKRGLSIEQL TTLAEKLLGPGVNYSGCQITWAKFC KENMAGKGFSFWVWLDNIIDLVKKY ILALWNEGYIMGFISKERERAILST KPPGTFLLRFSESSKEGGVTFTWVE KDISGKTQIQSVEPYTKQQLNNMSF AEIIMGYKIMDATNILVSPLVYLYP DIPKEEAFGKYCRPESQEHPEADPG SAAPYLKTKFICVTPFIDAVWKTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | STAT3 signal transducer and activator of transcription 3 [ Homo sapiens (human) ] |
Official Symbol : | STAT3 |
Synonyms : | STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF; DNA-binding protein APRF; acute-phase response factor; HIES; FLJ20882; MGC16063; |
Gene ID : | 6774 |
mRNA Refseq : | NM_213662 |
Protein Refseq : | NP_998827 |
MIM : | 102582 |
UniProt ID : | P40763 |
Products Types
◆ Recombinant Protein | ||
STAT3-6443H | Recombinant Human STAT3 protein, MBP&His-Avi-tagged, Biotinylated | +Inquiry |
STAT3-07H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
STAT3-5437R | Recombinant Rat STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT3-8786M | Recombinant Mouse STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Stat3-6170M | Recombinant Mouse Stat3 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
STAT3-1418HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
STAT3-1417HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
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