Recombinant Human STING1 R232, K224R mutant Protein, His-tagged

• Cat.No.: STING1-149H
• Product Overview: N-terminally Histidine-tagged human STING R232, K224R mutant purified from E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 138-379 (N-terminal truncation)
• Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
• Molecular Mass: 28.8 kDa
• Purity: ≥70% estimated by SDS-PAGE
• Stability: ≥ 1 year
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM HEPES, pH 8.0, with 150 mM sodium chloride, and 10% glycerol

Gene Information

• Gene Name: STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]
• Official Symbol: STING1
• Synonyms: STING1; stimulator of interferon response cGAMP interactor 1; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; mitochondrial mediator of IRF3 activation; stimulator of interferon protein; transmembrane protein 173
• Gene ID: 340061
• mRNA Refseq: NM_198282
• Protein Refseq: NP_938023
• MIM: 612374
• UniProt ID: Q86WV6