Recombinant Human SYT1

• Cat.No.: SYT1-31492TH
• Product Overview: Recombinant fragment, corresponding to amino acids 96-421 of Human Synaptotagmin 1.Note: SYT1-31492TH is mutated in the position I367T and contains a deletion of three amino acids 117A, 118L, and 119K

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 96-421 a.a.
• Description: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS, pH 7.3Note: Under these conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 500 μM.
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the synaptotagmin family.Contains 2 C2 domains.

Gene Information

• Gene Name: SYT1 synaptotagmin I [ Homo sapiens ]
• Official Symbol: SYT1
• Synonyms: SYT1; synaptotagmin I; SVP65, SYT; synaptotagmin-1; P65
• Gene ID: 6857
• mRNA Refseq: NM_001135805
• Protein Refseq: NP_001129277
• MIM: 185605
• Uniprot ID: P21579
• Chromosome Location: 12cen-q21
• Pathway: Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem; Botulinum neurotoxicity, organism-specific biosystem; Dopamine Neurotransmitter Release Cycle, organism-specific biosystem; Effects of Botulinum toxin, organism-specific biosystem; GABA synthesis, release, reuptake and degradation, organism-specific biosystem
• Function: 1-phosphatidylinositol binding; calcium ion binding; calcium-dependent protein binding; calmodulin binding; identical protein binding