Recombinant Human SYT1, His-tagged

• Cat.No.: SYT1-450H
• Product Overview: The protein was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 77-422aa
• Description: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: SYT1 synaptotagmin I [ Homo sapiens (human) ]
• Official Symbol: SYT1
• Synonyms: SYT1; P65; SYT; SVP65; synaptotagmin I; synaptotagmin-1; sytI; synaptotagmin 1
• Gene ID: 6857
• mRNA Refseq: NM_001135805
• Protein Refseq: NP_001129277
• MIM: 185605
• UniProt ID: P21579
• Chromosome Location: 12cen-q21
• Pathway: Acetylcholine Neurotransmitter Release Cycle; Botulinum neurotoxicity; Dopamine Neurotransmitter Release Cycle
• Function: 1-phosphatidylinositol binding; calcium ion binding; calcium-dependent phospholipid binding