| Description : |
Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. Plays a role in dendrite formation by melanocytes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.3 kDa |
| AA Sequence : |
MSGDYEDDLCRRALILVSDLCARVR DADTNDRCQEFNDRIRGYPRGPDAD ISVSLLSVIVTFCGIVLLGVSLFVS WKLCWVPWRDKGGSAVGGGPLRKDL GPGVGLAGLVGGGGHHLAAGLGGHP LLGGPHHHAHAAHHPPFAELLEPGS LGGSDTPEPSYLDMDSYPEAAAAAV AAGVKPSQTSPELPSEGGAGSGLLL LPPSGGGLPSAQSHQQVTSLAPTTR YPALPRPLTQQTLTSQPDPSSEERP PALPLPLPGGEEKAKLIGQIKPELY QGTGPGGRRSGGGPGSGEAGTGAPC GRISFALRYLYGSDQLVVRILQAMD LPAKDSNGFSDPYVKIYLLPDRKKK FQTKVHRKTLNPVFNETFQFSVPLA ELAQRKLHFSVYDFDRFSRHDLIGQ VVLDNLLELAEQPPDRPLWRDIVEG GSEKADLGELNFSLCYLPTAGRLTV TIIKASNLKAMDLTGFSDPYVKASL ISEGRRLKKRKTSIKKNTLNPTYNE ALVFDVAPESVENVGLSIAVVDYDC IGHNEVIGVCRVGPDAADPHGREHW AEMLANPRKPVEHWHQLVEEKTVTS FTKGSKGLSEKENSETRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
