Recombinant Human TAPBP Protein, MYC/DDK-tagged

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Recombinant Human TAPBP Protein, MYC/DDK-tagged

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Cat.No. : TAPBP-122H
Product Overview : Recombinant human TAPBP protein, fused to MYC/DDK-tag at C-terminal, was expressed in HEK293.
Description : This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 45.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : TAP binding protein [ Homo sapiens ]
Official Symbol : TAPBP
Synonyms : NGS17; TAPA; TPN; TPSN
Gene ID : 6892
mRNA Refseq : NM_003190.4
Protein Refseq : NP_003181.3
MIM : 601962
UniProt ID : O15533

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