Recombinant Human TBL1XR1 Protein, His-tagged

• Cat.No.: TBL1XR1-424H
• Product Overview: Recombinant Human TBL1XR1 fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 55.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 [ Homo sapiens ]
• Official Symbol: TBL1XR1
• Synonyms: TBL1XR1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta) like 1X linked receptor 1; F-box-like/WD repeat-containing protein TBL1XR1; C21; DC42; FLJ12894; IRA1; TBLR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1
• Gene ID: 79718
• mRNA Refseq: NM_024665
• Protein Refseq: NP_078941
• MIM: 608628
• UniProt ID: Q9BZK7