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| Cat.No.: | TEK-2054H |
| Product Overview: | Recombinant Human Tie2/CD202b/TEK Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala23-Lys745) of human Tie2/CD202b/TEK (Accession #NP_000450.2) fused with an Fc, 6×His tag at the C-terminus. |
| Description: | The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.) This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. TEK has also been suggested as a marker for nucleus pulposus progenitor cells, from the intervertebral disc, which upon activation by Angiopoietin-1 starts to multiply and differentiate. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. |
| Source: | HEK293 |
| Species: | Human |
| Tag : | Fc/His |
| Form: | Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol. |
| Protein length: | Ala23-Lys745 |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Purity: | > 90% as determined by SDS-PAGE |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70ºC. |
| Storage: | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name: | TEK TEK tyrosine kinase, endothelial [ Homo sapiens ] |
| Official Symbol: | TEK |
| Synonyms: | TEK; TEK tyrosine kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; TIE 2; TIE2; VMCM1; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine kinase with Ig and EGF homology domains-2; VMCM; TIE-2; CD202B; |
| Gene ID: | 7010 |
| mRNA Refseq: | NM_000459 |
| Protein Refseq: | NP_000450 |
| MIM: | 600221 |
| UniProt ID: | Q02763 |
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