Active Recombinant Human TEK Protein, hIgG/His-tagged
Cat.No. : | TEK-008H |
Product Overview : | Recombinant Human TEK Protein (23-748aa) with hIgG/His tag was expressed in insect cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
Source : | Insect Cells |
Species : | Human |
Tag : | hIgG/His |
Form : | Liquid |
Bio-activity : | Measured by the ability of the binding activity in a functional ELISA. The ED50 range ≤1 µg/ml. |
Molecular Mass : | 107.9 kDa (965aa) |
Protein length : | 23-748aa |
AA Sequence : | AMDLILINSLPLVSDAETSLTCIAS GWRPHEPITIGRDFEALMNQHQDPL EVTQDVTREWAKKVVWKREKASKIN GAYFCEGRVRGEAIRIRTMKMRQQA SFLPATLTMTVDKGDNVNISFKKVL IKEEDAVIYKNGSFIHSVPRHEVPD ILEVHLPHAQPQDAGVYSARYIGGN LFTSAFTRLIVRRCEAQKWGPECNH LCTACMNNGVCHEDTGECICPPGFM GRTCEKACELHTFGRTCKERCSGQE GCKSYVFCLPDPYGCSCATGWKGLQ CNEACHPGFYGPDCKLRCSCNNGEM CDRFQGCLCSPGWQGLQCEREGIPR MTPKIVDLPDHIEVNSGKFNPICKA SGWPLPTNEEMTLVKPDGTVLHPKD FNHTDHFSVAIFTIHRILPPDSGVW VCSVNTVAGMVEKPFNISVKVLPKP LNAPNVIDTGHNFAVINISSEPYFG DGPIKSKKLLYKPVNHYEAWQHIQV TNEIVTLNYLEPRTEYELCVQLVRR GEGGEGHPGPVRRFTTASIGLPPPR GLNLLPKSQTTLNLTWQPIFPSSED DFYVEVERRSVQKSDQQNIKVPGNL TSVLLNNLHPREQYVVRARVNTKAQ GEWSEDLTAWTLSDILPPQPENIKI SNITHSSAVISWTILDGYSISSITI RYKVQGKNEDQHVDVKIKNATITQY QLKGLEPETAYQVDIFAENNIGSSN PAFSHELVTLPESQAPADLGGGKML L |
Endotoxin : | < 1 EU per 1 µg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE, Bioactivity |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/mL (determined by Bradford assay) |
Storage Buffer : | In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Name : | TEK TEK receptor tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | TEK |
Synonyms : | TEK; TEK receptor tyrosine kinase; TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B; angiopoietin-1 receptor; TEK tyrosine kinase, endothelial; endothelial tyrosine kinase; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2; EC 2.7.10.1 |
Gene ID : | 7010 |
mRNA Refseq : | NM_000459 |
Protein Refseq : | NP_000450 |
MIM : | 600221 |
UniProt ID : | Q02763 |
Products Types
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◆ Lysates | ||
TEK-1065CCL | Recombinant Cynomolgus TEK cell lysate | +Inquiry |
TEK-415HCL | Recombinant Human TEK cell lysate | +Inquiry |
TEK-404MCL | Recombinant Mouse TEK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
Seamless delivery process—ordered, received, and ready for experiments.
Courteous and efficient customer service made our purchase hassle-free.
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