| Description : |
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
61.5 kDa |
| AA Sequence : |
MSHAAEPARDGVEASAEGPRAVFVL LEERRPADSAQLLSLNSLLPESGIV ADIELENVLDPDSFYELKSQPLPLR SSLPISLQATPATPATLSASSSAGG SRTPAMSSSSSSRVLLRQQLMRAQA QEQERRERREQAAAAPFPSPAPASP AISVVGVSAGGHTLSRPPPAQVPRE VLKVQTHLENPTRYHLQQARRQQVK QYLSTTLGPKLASQALTPPPGPASA QPLPAPEAAHTTGPTGSAPNSPMAL LTIGSSSEKEIDDVIDEIISLESSY NDEMLSYLPGGTTGLQLPSTLPVSG NLLDVYSSQGVATPAITVSNSCPAE LPNIKREISETEAKALLKERQKKDN HNLIERRRRFNINDRIKELGTLIPK SSDPEMRWNKGTILKASVDYIRKLQ KEQQRSKDLESRQRSLEQANRSLQL RIQELELQAQIHGLPVPPTPGLLSL ATTSASDSLKPEQLDIEEEGRPGAA TFHVGGGPAQNAPHQQPPAPPSDAL LDLHFPSDHLGDLGDPFHLGLEDIL MEEEEGVVGGLSGGALSPLRAASDP LLSSVSPAVSKASSRRSSFSMEEES TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
