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Recombinant Human TIE1 protein, His & T7-tagged

Cat.No. : TIE1-533H
Product Overview : Recombinant Human TIE1 aa. (Thr701~Pro898 (Accession # P35590)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 25.7kDa
Protein length : Thr701~Pro898 (Accession # P35590)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.6.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4
Gene Name : TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 [ Homo sapiens (human) ]
Official Symbol : TIE1
Synonyms : TIE1; tyrosine kinase with immunoglobulin like and EGF like domains 1; TIE; JTK14; tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Gene ID : 7075
mRNA Refseq : NM_005424.4
Protein Refseq : NP_005415.1
UniProt ID : P35590

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can I increase the expression level of TIE1 protein? 02/25/2022

At present, there is no direct way to increase the expression level of TIE1 protein, but it can be improved by regulating gene expression and providing nutritional support.

What are the applications of TIE1 protein in drug discovery? 12/10/2020

This protein can be used as a target for the development of new drugs, or as a drug carrier for the targeted delivery of drugs.

What is the current state of development for TIE1? 12/04/2020

TIE1 is currently in clinical trials, including small molecule inhibitors against TIE1 and inhibitors against the TIE1 signaling pathway.

How can TIE1 be used as a biomarker in clinical practice? 06/07/2020

In clinical practice, the expression level of TIE1 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of angiogenesis-related diseases, measuring the expression level of TIE1 can help doctors determine the type, stage, and prognosis of the disease, and guide the choice of treatment regimen.

What is the significance of studying the TIE1 protein? 05/06/2020

TIE1 protein can shed light on the mechanisms of angiogenesis and embryonic development, as well as the pathogenesis of certain angiogenesis-related diseases. In addition, it is of great significance for the development of new drugs and treatment strategies.

How about TIE1 protein related to autoimmune diseases? 02/21/2020

Studies have shown that TIE1 protein plays an important role in the pathogenesis of certain autoimmune diseases.

Customer Reviews (3)

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Reviews
12/19/2022

    After repeated use, it can also maintain the stability of the performance, which makes me more confident in the experimental results.

    06/11/2022

      Green and pollution-free, it can be seen that the manufacturer is very environmentally conscious.

      01/29/2021

        The range of applications is breathtaking, and it can play an important role in any field.

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