Recombinant Human TIGIT protein, His-tagged
Cat.No. : | TIGIT-106H |
Product Overview : | Recombinant Human TIGIT(Met 22 - Pro 141) fused with His tag at C-terminal was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met 22 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Has a calculated MW of 15 kDa. The reducing (R) protein migrates as 18-24 kDa in SDS-PAGE due to glycosylation. |
Protein length : | Met 22 - Pro 141 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade). |
Publication : |
Structural and functional characterization of a monoclonal antibody blocking TIGIT (2022)
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Gene Name : | TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens ] |
Official Symbol : | TIGIT |
Synonyms : | TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM; |
Gene ID : | 201633 |
mRNA Refseq : | NM_173799 |
Protein Refseq : | NP_776160 |
MIM : | 612859 |
UniProt ID : | Q495A1 |
Chromosome Location : | 3q13.31 |
Function : | protein binding; |
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◆ Lysates | ||
TIGIT-1420MCL | Recombinant Mouse TIGIT cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.
TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.
TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.
TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.
As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.
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