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Recombinant Human TIGIT Protein (Met22-Pro141, A103), C-Fc-tagged
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Cat.No. : | TIGIT-356H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human TIGIT Protein (Met22-Pro141, A103) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Chinese Hamster Ovary cell line. |
Description : | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. |
Source : | CHO |
Species : | Human |
Tag : | C-Fc |
Form : | Disulfide-linked homodimer |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Human CD155/PVR (Catalog # 2530-CD) is coated at 2.5 μg/mL (100 μL/well), the concentration of Recombinant Human TIGIT (A103) Fc Chimera that produces 50% optimal binding response is 40-200 ng/mL. |
Molecular Mass : | Predicted Molecular Mass: 40 kDa SDS-PAGE: 40-53 kDa, reducing conditions |
Protein Length : | Met22-Pro141, A103 |
N-terminal Sequence Analysis : | Met22 |
Endotoxin : | < 0.10 EU/μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, ≤ -20 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, ≤ -20 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. |
Binding Activity : |
![]() When Recombinant Human CD155/PVR is immobilized at 2.5 μg/mL, Recombinant Human TIGIT (A103) Fc Chimera binds with an ED50 of 40-200 ng/mL. |
Gene Name : | TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens (human) ] |
Official Symbol : | TIGIT |
Synonyms : | TIGIT; T cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; WUCAM; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9, VSTM3; Washington University cell adhesion molecule |
Gene ID : | 201633 |
mRNA Refseq : | NM_173799 |
Protein Refseq : | NP_776160 |
MIM : | 612859 |
UniProt ID : | Q495A1 |
◆ Recombinant Protein
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Tigit-016M | Recombinant Mouse Tigit Protein, MYC/DDK-tagged | +Inquiry |
TIGIT-163H | Recombinant Human TIGIT Protein | +Inquiry |
TIGIT-1037H | Recombinant Human TIGIT Protein, MYC/DDK-tagged | +Inquiry |
TIGIT-306H | Recombinant Human TIGIT Protein (ECD), His-tagged(C-ter) | +Inquiry |
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◆ Lysates
TIGIT-2610HCL | Recombinant Human TIGIT cell lysate | +Inquiry |
TIGIT-1420MCL | Recombinant Mouse TIGIT cell lysate | +Inquiry |
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