Recombinant Human TMEM173 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: TMEM173-3290H
• Product Overview: TMEM173 MS Standard C13 and N15-labeled recombinant protein (NP_938023) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42.2 kDa
• AA Sequence: MPHSSLHPSIPCPRGHGAQKAALVL LSACLVTLWGLGEPPEHTLRYLVLH LASLQLGLLLNGVCSLAEELRHIHS RYRGSYWRTVRACLGCPLRRGALLL LSIYFYYSLPNAVGPPFTWMLALLG LSQALNILLGLKGLAPAEISAVCEK GNFNVAHGLAWSYYIGYLRLILPEL QARIRTYNQHYNNLLRGAVSQRLYI LLPLDCGVPDNLSMADPNIRFLDKL PQQTGDHAGIKDRVYSNSIYELLEN GQRAGTCVLEYATPLQTLFAMSQYS QAGFSREDRLEQAKLFCRTLEDILA DAPESQNNCRLIAYQEPADDSSFSL SQEVLRHLRQEEKEEVTVGSLKTSA VPSTSTMSQEPELLISGMEKPLPLR TDFSTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: TMEM173 transmembrane protein 173 [ Homo sapiens (human) ]
• Official Symbol: TMEM173
• Synonyms: TMEM173; transmembrane protein 173; FLJ38577; NET23; hMITA; hSTING; mediator of IRF3 activation; endoplasmic reticulum IFN stimulator; stimulator of interferon genes protein; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; ERIS; MITA; MPYS; STING
• Gene ID: 340061
• mRNA Refseq: NM_198282
• Protein Refseq: NP_938023
• MIM: 612374
• UniProt ID: Q86WV6