Recombinant Human TMPRSS2 protein, His-SUMO-tagged

• Cat.No.: TMPRSS2-4593H
• Product Overview: Recombinant Human TMPRSS2 protein(O15393)(106-492aa), fused to N-terminal His tag and SUMO tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His&SUMO
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Protein length: 106-492aa
• AA Sequence: WKFMGSKCSNSGIECDSSGTCINPS NWCDGVSHCPGGEDENRCVRLYGPN FILQVYSSQRKSWHPVCQDDWNENY GRAACRDMGYKNNFYSSQGIVDDSG STSFMKLNTSAGNVDIYKKLYHSDA CSSKAVVSLRCIACGVNLNSSRQSR IVGGESALPGAWPWQVSLHVQNVHV CGGSIITPEWIVTAAHCVEKPLNNP WHWTAFAGILRQSFMFYGAGYQVEK VISHPNYDSKTKNNDIALMKLQKPL TFNDLVKPVCLPNPGMMLQPEQLCW ISGWGATEEKGKTSEVLNAAKVLLI ETQRCNSRYVYDNLITPAMICAGFL QGNVDSCQGDSGGPLVTSKNNIWWL IGDTSWGSGCAKAYRPGVYGNVMVF TDWIYRQMRADG
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: TMPRSS2 transmembrane protease, serine 2 [ Homo sapiens ]
• Official Symbol: TMPRSS2
• Synonyms: TMPRSS2; transmembrane protease, serine 2; transmembrane protease serine 2; PRSS10; epitheliasin; serine protease 10; PP9284; FLJ41954
• Gene ID: 7113
• mRNA Refseq: NM_001135099
• Protein Refseq: NP_001128571
• MIM: 602060
• UniProt ID: O15393

Reviews

02/04/2021

Stable and did not change significantly during storage and transportation.

04/25/2020

High solubility makes it easy to prepare the desired concentration.

05/13/2019

The protein had good crystallinity, which was beneficial for crystallographic study.

Q&As

Are there regulators related to the regulation of TMPRSS2 protein expression?

Yes, transcription factors and signaling pathways have been identified that are associated with the regulation of the expression of TMPRSS2 proteins, which regulate the expression levels and activity of TMPRSS2 proteins.

What is the use of TMPRSS2 protein in laboratory diagnostics?

TMPRSS2 protein can be used to aid the diagnosis of certain tumors. Measuring the expression level of TMPRSS2 proteins in tumor tissues can be used as an auxiliary marker to determine disease type and prognosis.

What is the role of TMPRSS2 protein in viral infection?

TMPRSS2 proteins play an important role in some viral infections. For example, in novel coronavirus (SARS-CoV-2) infection, TMPRSS2 proteins facilitate the entry of the virus into host cells.

Are there proteins that interact with TMPRSS2 proteins?

Yes, proteins that interact with TMPRSS2 proteins have been discovered, including viral proteins, cell surface receptors, etc. These interactions are involved in biological processes such as viral invasion and cell signaling.

What is the current research progress on TMPRSS2 proteins?

Research on TMPRSS2 protein is going on. At present, it mainly focuses on the analysis of its function, the identification of gene mutations associated with diseases, and the interaction with other proteins, providing a theoretical basis for further understanding of diseases related to TMPRSS2 proteins.

Is the expression level of TMPRSS2 protein in lung cancer related to prognosis?

Some studies have shown that high expression of TMPRSS2 protein in lung cancer may be associated with a poorer prognosis. However, the specific mechanisms need to be further studied to confirm.