Recombinant Human TMPRSS2 Protein, His-tagged

• Cat.No.: TMPRSS2-086H
• Product Overview: Recombinant protein of the extracellular domain (M109-G492) of human transmembrane protease serine 2 (TMPRSS2), with an c-terminal polyhistidine tag was expressed in human cells.

Specification

• Description: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Human cells
• Species: Human
• Tag: His
• Molecular Mass: 49 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/μg of protein (< 1 EU /μg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Gene Information

• Gene Name: TMPRSS2 transmembrane serine protease 2 [ Homo sapiens (human) ]
• Official Symbol: TMPRSS2
• Synonyms: TMPRSS2; transmembrane serine protease 2; PRSS10; transmembrane protease serine 2; epitheliasin; serine protease 10; transmembrane protease, serine 2; EC 3.4.21.-
• Gene ID: 7113
• mRNA Refseq: NM_005656
• Protein Refseq: NP_005647
• MIM: 602060
• UniProt ID: O15393