Recombinant Human TNF, Biotinylated
Cat.No. : | TNF-279H |
Product Overview : | Human TNF-alpha Protein, Biotinylated (Biotinylated TNFa) Val 77 - Leu 233, was labeled with biotin based on rhTNFα Protein, which was produced in human 293 cells (HEK293).? |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.? |
Source : | HEK293 |
Species : | Human |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Biotinylated TNFa, contains no "tag", has a calculated MW of 26 kDa. The predicted N-terminus is Val 77. DTT-reduced Protein migrates as 18kDa. |
Endotoxin : | Less than 1.0 EU per μg of the Biotinylated TNFa by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). |
Gene Name : | TNF tumor necrosis factor [ Homo sapiens ] |
Official Symbol : | TNF |
Synonyms : | TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2; TNFA; TNF-alpha; |
Gene ID : | 7124 |
mRNA Refseq : | NM_000594 |
Protein Refseq : | NP_000585 |
MIM : | 191160 |
UniProt ID : | P01375 |
Chromosome Location : | 6p21.3 |
Pathway : | Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; |
Function : | cytokine activity; identical protein binding; protease binding; protein binding; transcription regulatory region DNA binding; tumor necrosis factor receptor binding; |
Products Types
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TNF-437R | Recombinant Rabbit TNF Protein, His&GST-tagged | +Inquiry |
Tnf-147T | Active Recombinant Rat Tnf Protein (157 aa) | +Inquiry |
TNF-1998M | Recombinant Mouse TNF Protein | +Inquiry |
◆ Lysates | ||
TNF-897HCL | Recombinant Human TNF 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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