Recombinant Human TNF Protein, His-tagged TNF-02H

Recombinant Human TNF Protein, His-tagged

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Recombinant Human TNF Protein, His-tagged

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Cat.No. : TNF-02H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human Tumor necrosis factor alpha (TNFα, TNF-α) soluble form (P01375|77-233) with a C-terminal His-tag was produced in Nicotiana benthamiana by Agrobacterium-mediated transient expression.
Description : This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Source : Nicotiana benthamiana
Species : Human
Tag : His
Form : Lyophilized
Molecular Mass : 19.1 kDa (+ Glycosylation)
Protein length : 77-233
Purity : 97%
Storage : Lyophilized materials are stable for up to twelve months from date of receipt at -70 centigrade.
It is recommended that reconstituted protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS pH7.4, 175 mM Trehalose.
Shipping : At ambient temperature.
SDS-PAGE :

Reducing 4-20% SDS-PAGE analysis of 6 µg TNFα.

Gene Name : TNF tumor necrosis factor [ Homo sapiens (human) ]
Official Symbol : TNF
Synonyms : TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha; tumor necrosis factor; APC1 protein; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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