Cat.No. :	TNFA-386H
Product Overview :	Recombinant Human TNFA Protein is produced by Bacteria expression system. This protein is fused with a GST tag.
Description :	TNFalpha (Tumor necrosis factor alpha) is produced by immune and epithelial cells. It plays important roles in regulating inflammation, apoptosis, and immune response. It exerts its function mainly by binding of two cell surface receptors TNFR1 and TNFR2. Treating cells with TNFalpha activates the NFkappaB, MAPK, and apoptotic signaling pathways. The recombinant GST-TNFalpha protein consists of a N-terminal GT tag with the C-terminal extracellular domain (amino acids 77-233) of full length TNFalpha. It can be used for pulldown assays. It binds TNFR1 and TNFR2 to induce downstream signaling pathways, but often requires higher concentrations than TNFalpha.
Source :	Bacteria
Species :	Human
Tag :	GST
Form :	20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
Molecular Mass :	25.6 kDa
Purity :	> 85 % by SDS-PAGE
Storage :	Store at -80 centigrade; avoid multiple freeze-thaw cycles.

Gene Name :	TNF tumor necrosis factor [ Homo sapiens (human) ]
Official Symbol :	TNF
Synonyms :	TNF; DIF; TNFA; TNFSF2; TNF-alpha
Gene ID :	7124
mRNA Refseq :	NM_000594.3
Protein Refseq :	NP_000585
MIM :	191160
UniProt ID :	P01375

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