| Description : |
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
60.2 kDa |
| Protein Length : |
655 |
| AA Sequence : |
MGTSPSSSTALASCSRIARRATATM IAGSLLLLGFLSTTTAQPEQKASNL IGTYRHVDRATGQVLTCDKCPAGTY VSEHCTNTSLRVCSSCPVGTFTRHE NGIEKCHDCSQPCPWPMIEKLPCAA LTDRECTCPPGMFQSNATCAPHTVC PVGWGVRKKGTETEDVRCKQCARGT FSDVPSSVMKCKAYTDCLSQNLVVI KPGTKETDNVCGTLPSFSSSTSPSP GTAIFPRPEHMETHEVPSSTYVPKG MNSTESNSSASVRPKVLSSIQEGTV PDNTSSARGKEDVNKTLPNLQVVNH QQGPHHRHILKLLPSMEATGGEKSS TPIKGPKRGHPRQNLHKHFDINEHL PWMIVLFLLLVLVVIVVCSIRKSSR TLKKGPRQDPSAIVEKAGLKKSMTP TQNREKWIYYCNGHGIDILKLVAAQ VGSQWKDIYQFLCNASEREVAAFSN GYTADHERAYAALQHWTIRGPEASL AQLISALRQHRRNDVVEKIRGLMED TTQLETDKLALPMSPSPLSPSPIPS PNAKLENSALLTVEPSPQDKNKGFF VDESEPLLRCDSTSSGSSALSRNGS FITKEKKDTVLRQVRLDPCDLQPIF DDMLHFLNPEELRVIEEIPQAEDKL DRLFEIIGVKSQEASQTLLDSVYSH LPDLL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
