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Active Recombinant Human TNFSF11 protein, Avi-Fc-tagged, Biotinylated

Cat.No. : TNFSF11-209H
Product Overview : Biotinylated Recombinant Human TNFSF11 protein(Gly 64 - Asp 245), fused with Avi-Fc tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : Avi-Fc
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Bio-activity : Immobilized Human RANK, Mouse IgG2a Fc Tag, low endotoxin at 0.5 μg/mL (100 μL/well) can bind Biotinylated Human TNFSF11, Avitag,Fc Tag with a linear range of 0.4-13 ng/mL. Immobilized Human OPG, Fc Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human TNFSF11, Avitag,Fc Tag with a linear range of 0.3-10 ng/mL.
Molecular Mass : This protein carries an Avi tag (Avitag) at the N-terminus, followed by a human IgG1 Fc tag.The protein has a calculated MW of 49.2 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Gly 64 - Asp 245
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 [ Homo sapiens ]
Official Symbol : TNFSF11
Synonyms : TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; sOdf; OPTB2; hRANKL2;
Gene ID : 8600
mRNA Refseq : NM_003701
Protein Refseq : NP_003692
MIM : 602642
UniProt ID : O14788

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How can the expression level of TNFSF11 protein be used for disease diagnosis and prognosis assessment? 09/19/2022

It is possible to detect the expression level of TNFSF11 protein to help diagnose tumors and other diseases, and to assess their prognosis and treatment effectiveness.

How to use the activity of TNFSF11 protein for disease treatment? 03/14/2022

At present, a variety of drugs have been developed to target TNFSF11 proteins and their related signaling pathways, including inhibiting their expression and inhibiting their binding to receptors, etc., for the treatment of tumors and other bone metabolism-related diseases.

What is the relationship between TNFSF11 proteins and infectious diseases? 08/11/2021

Studies have shown that TNFSF11 proteins can be involved in the regulation of infectious diseases, such as playing a role in some viral infections.

How well are TNFSF11 proteins expressed in different tissues and organs? 10/06/2020

There are differences in the expression of TNFSF11 proteins in different tissues and organs, and they are expressed in tissues and organs such as the immune system, bones, and teeth, and the expression level may be affected by many factors.

What is the relationship between TNFSF11 proteins and autoimmune diseases? 04/02/2020

Studies have shown that TNFSF11 proteins can be involved in the regulation of autoimmune diseases, such as in autoimmune diseases such as rheumatoid arthritis.

What is the relationship between TNFSF11 proteins and other TNF superfamily members? 01/31/2019

TNFSF11 protein belongs to the TNF superfamily and has certain structural and functional similarities with other members of the TNF superfamily.

Customer Reviews (3)

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Reviews
10/14/2022

    The reproducibility of TNFSF11 is so good that the results are highly consistent regardless of the conditions under which the experiment or application is performed, greatly reducing the experimental error.

    11/24/2020

      Green production process of TNFSF11 is highly commendable, which uses the most advanced biotechnology to increase production efficiency and reduce environmental impact.

      07/22/2020

        The short half-life and high clearance of TNFSF11 make it better able to adapt to changing treatment needs and provide patients with more flexible treatment options.

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