| Description : |
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
213.4 kDa |
| AA Sequence : |
MDPTGSQLDSDFSQQDTPCLIIEDS QPESQVLEDDSGSHFSMLSRHLPNL QTHKENPVLDVVSNPEQTAGEERGD GNSGFNEHLKENKVADPVDSSNLDT CGSISQVIEQLPQPNRTSSVLGMSV ESAPAVEEEKGEELEQKEKEKEEDT SGNTTHSLGAEDTASSQLGFGVLEL SQSQDVEENTVPYEVDKEQLQSVTT NSGYTRLSDVDANTAIKHEEQSNED IPIAEQSSKDIPVTAQPSKDVHVVK EQNPPPARSEDMPFSPKASVAAMEA KEQLSAQELMESGLQIQKSPEPEVL STQEDLFDQSNKTVSSDGCSTPSRE EGGCSLASTPATTLHLLQLSGQRSL VQESLSTNSSDLVAPSPDAFRSTPF IVPSSPTEQEGRQDKPMDTSVLSEE GGEPFQKKLQSSEPVELENPPLLPE STVSPQASTPISQSTPVFPPGSLPI PSQPQFSHDIFIPSPSLEEQSNDGK KDGDMHSSSLTVECSKTSEIEPKNS PEDLGLSLTGDSCKLMLSTSEYSQS PKMESLSSHRIDEDGENTQIEDTEP MSPVLNSKFVPAENDSILMNPAQDG EVQLSQNDDKTKGDDTDTRDDISIL ATGCKGREETVAEDVCIDLTCDSGS QAVPSPATRSEALSSVLDQEEAMEI KEHHPEEGSSGSEVEEIPETPCESQ GEELKEENMESVPLHLSLTETQSQG LCLQKEMPKKECSEAMEVETSVISI DSPQKLAILDQELEHKEQEAWEEAT SEDSSVVIVDVKEPSPRVDVSCEPL EGVEKCSDSQSWEDIAPEIEPCAEN RLDTKEEKSVEYEGDLKSGTAETEP VEQDSSQPSLPLVRADDPLRLDQEL QQPQTQEKTSNSLTEDSKMANAKQL SSDAEAQKLGKPSAHASQSFCESSS ETPFHFTLPKEGDIIPPLTGATPPL IGHLKLEPKRHSTPIGISNYPESTI ATSDVMSESMVETHDPILGSGKGDS GAAPDVDDKLCLRMKLVSPETEASE ESLQFNLEKPATGERKNGSTAVAES VASPQKTMSVLSCICEARQENEARS EDPPTTPIRGNLLHFPSSQGEEEKE KLEGDHTIRQSQQPMKPISPVKDPV SPASQKMVIQGPSSPQGEAMVTDVL EDQKEGRSTNQENPSKALIERPSQN NIGIQTMECSLRVPETVSAATQTIK NVCEQGTSTVDQNFGKQDATVQTER GSGEKPVSAPGDDTESLHSQGEEEF DMPQPPHGHVLHRHMRTIREVRTLV TRVITDVYYVDGTEVERKVTEETEE PIVECQECETEVSPSQTGGSSGDLG DISSFSSKASSLHRTSSGTSLSAMH SSGSSGKGAGPLRGKTSGTEPADFA LPSSRGGPGKLSPRKGVSQTGTPVC EEDGDAGLGIRQGGKAPVTPRGRGR RGRPPSRTTGTRETAVPGPLGIEDI SPNLSPDDKSFSRVVPRVPDSTRRT DVGAGALRRSDSPEIPFQAAAGPSD GLDASSPGNSFVGLRVVAKWSSNGY FYSGKITRDVGAGKYKLLFDDGYEC DVLGKDILLCDPIPLDTEVTALSED EYFSAGVVKGHRKESGELYYSIEKE GQRKWYKRMAVILSLEQGNRLREQY GLGPYEAVTPLTKAADISLDNLVEG KRKRRSNVSSPATPTASSSSSTTPT RKITESPRASMGVLSGKRKLITSEE ERSPAKRGRKSATVKPGAVGAGEFV SPCESGDNTGEPSALEEQRGPLPLN KTLFLGYAFLLTMATTSDKLASRSK LPDGPTGSSEEEEEFLEIPPFNKQY TESQLRAGAGYILEDFNEAQCNTAY QCLLIADQHCRTRKYFLCLASGIPC VSHVWVHDSCHANQLQNYRNYLLPA GYSLEEQRILDWQPRENPFQNLKVL LVSDQQQNFLELWSEILMTGGAASV KQHHSSAHNKDIALGVFDVVVTDPS CPASVLKCAEALQLPVVSQEWVIQC LIVGERIGFKQHPKYKHDYVSHTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
