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Recombinant Human TPBG Protein, Fc-tagged

Cat.No.: TPBG-32H
Product Overview: Recombinant human TPBG-Fc fusion is expressed as a 561 amino acid protein consisting of Ser32 - Ser355 region of TPBG and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing condition.
Description: TPBG (trophoblast glycoprotein), also known as oncofetal antigen 5T4 and WAIF1 (wnt-activated inhibitory factor 1), is a single-pass type I transmembrane glycoprotein of the LRR (leucine-rich repeat) protein family. TPBG is an oncofetal antigen that is specific to trophoblast cells except for amniotic epithelium. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development. In adults its expression is limited to a few epithelial cell types but highly abundant in many types of tumor cells. TPBG’s expression is associated with poor clinical outcome in numerous cancers. TPBG contains 1 LRRNT (LRR N-terminal cap), 7 LRR (LRR1-7), and 1 LRRCT (LRR C-terminal cap) domains in the extracellular region. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. The C-terminal part of LRRNT and LRR1 are essential for the inhibition of the Wnt signaling pathway. TPBG may also be involved in cell adhesion and motility.
Source: Human cells
Species: Human
Tag : Fc
Molecular Mass: Calculated molecular mass (kDa): 62; Estimated by SDS-PAGE under reducing condition (kDa): 90-100
AA Sequence: SSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSTTENLYFQGSTGTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Endotoxin: <0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Purity: >95% judged by SDS-PAGE under reducing condition.
Notes: FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE IN HUMAN.
Storage Buffer: Supplied at 0.5 mg/mL in sterile PBS pH7.4 (carrier & preservative free).
Gene Name: TPBG trophoblast glycoprotein [ Homo sapiens (human) ]
Official Symbol: TPBG
Synonyms: TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4M6P1; trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1
Gene ID: 7162
mRNA Refseq: NM_001166392
Protein Refseq: NP_001159864
MIM: 190920
UniProt ID: Q13641

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