Recombinant Human TPBG Protein, Fc-tagged

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Recombinant Human TPBG Protein, Fc-tagged

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Cat.No. : TPBG-32H
Product Overview : Recombinant human TPBG-Fc fusion is expressed as a 561 amino acid protein consisting of Ser32 - Ser355 region of TPBG and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing condition.
Description : TPBG (trophoblast glycoprotein), also known as oncofetal antigen 5T4 and WAIF1 (wnt-activated inhibitory factor 1), is a single-pass type I transmembrane glycoprotein of the LRR (leucine-rich repeat) protein family. TPBG is an oncofetal antigen that is specific to trophoblast cells except for amniotic epithelium. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development. In adults its expression is limited to a few epithelial cell types but highly abundant in many types of tumor cells. TPBG’s expression is associated with poor clinical outcome in numerous cancers. TPBG contains 1 LRRNT (LRR N-terminal cap), 7 LRR (LRR1-7), and 1 LRRCT (LRR C-terminal cap) domains in the extracellular region. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. The C-terminal part of LRRNT and LRR1 are essential for the inhibition of the Wnt signaling pathway. TPBG may also be involved in cell adhesion and motility.
Source : Human cells
Species : Human
Tag : Fc
Molecular Mass : Calculated molecular mass (kDa): 62; Estimated by SDS-PAGE under reducing condition (kDa): 90-100
AA Sequence : SSPTSSASSFSSSAP FLASAVSAQPPLPDQ CPALCECSEAARTVK CVNRNLTEVPTDLPA YVRNLFLTGNQLAVL PAGAFARRPPLAELA ALNLSGSRLDEVRAG AFEHLPSLRQLDLSH NPLADLSPFAFSGSN ASVSAPSPLVELILN HIVPPEDERQNRSFE GMVVAALLAGRALQG LRRLELASNHFLYLP RDVLAQLPSLRHLDL SNNSLVSLTYVSFRN LTHLESLHLEDNALK VLHNGTLAELQGLPH IRVFLDNNPWVCDCH MADMVTWLKETEVVQ GKDRLTCAYPEKMRN RVLLELNSADLDCDP ILPPSLQTSTTENLY FQGSTGTHTCPPCPA PELLGGPSVFLFPPK PKDTLMISRTPEVTC VVVDVSHEDPEVKFN WYVDGVEVHNAKTKP REEQYNSTYRVVSVL TVLHQDWLNGKEYKC KVSNKALPAPIEKTI SKAKGQPREPQVYTL PPSREEMTKNQVSLT CLVKGFYPSDIAVEW ESNGQPENNYKTTPP VLDSDGSFFLYSKLT VDKSRWQQGNVFSCS VMHEALHNHYTQKSL SLSPGK
Endotoxin : <0.1 EU per 1 μg of purified recombinant protein determined by the LAL method
Purity : >95% judged by SDS-PAGE under reducing condition.
Notes : FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE IN HUMAN.
Storage Buffer : Supplied at 0.5 mg/mL in sterile PBS pH7.4 (carrier & preservative free).
Figure :

Gene Name : TPBG trophoblast glycoprotein [ Homo sapiens (human) ]
Official Symbol : TPBG
Synonyms : TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4M6P1; trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1
Gene ID : 7162
mRNA Refseq : NM_001166392
Protein Refseq : NP_001159864
MIM : 190920
UniProt ID : Q13641

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