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Recombinant Human Transforming Growth Factor, Beta 1, GST-tagged

Cat.No. : TGFB1-119H
Product Overview : Recombinant Human TGF-b 1 (177-391 a.a.) produced inE.coliis purified by standard chromatographic techniques and shows a 51 kDa band on SDS-PAGE (including GST tag).
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  • Gene Information
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Cat. No. : TGFB1-119H
Description : Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered solution at a concentration of 0.1 mg/ml.
Purity : Greater than 80.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein solution contains 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Amino Acid Sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Leu-Asp-Thr-Asn.
Storage : TGF-beta 1 although stable at 4°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Gene Name : TGFB1 transforming growth factor, beta 1 [ Homo sapiens ]
Synonyms : TGFB1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Latency-associated peptide; LAP
Gene ID : 7040
mRNA Refseq : NM_000660
Protein Refseq : NP_000651
MIM : 190180
UniProt ID : P01137
Chromosome Location : 19q13.1
Pathway : Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis; Influenza Infection; Signaling by TGF beta
Function : growth factor activity; protein N-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription activator activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is TGFB1 involved in bone remodeling? 08/04/2020

TGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.

Are there any side effects associated with therapies targeting TGFB1? 10/09/2019

Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.

Can TGFB1 be used as a biomarker for certain diseases? 04/11/2017

TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.

In what ways does TGFB1 influence wound healing? 05/15/2016

TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.

How does TGFB1 contribute to fibrosis? 05/06/2016

TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.

Customer Reviews (3)

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Reviews
11/16/2021

    The impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

    03/01/2020

      Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

      07/16/2018

        The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.

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