Recombinant Human TSHR, MYC/DDK-tagged

• Cat.No.: TSHR-839H
• Product Overview: Recombinant Human TSHR fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 28.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: TSHR thyroid stimulating hormone receptor [ Homo sapiens (human) ]
• Official Symbol: TSHR
• Synonyms: TSHR; LGR3; CHNG1; hTSHR-I; thyroid stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
• Gene ID: 7253
• mRNA Refseq: NM_001142626
• Protein Refseq: NP_001136098
• MIM: 603372
• UniProt ID: P16473
• Chromosome Location: 14q31
• Pathway: Arf6 signaling events; Autoimmune thyroid disease; G alpha (s) signalling events
• Function: protein binding; thyroid-stimulating hormone receptor activity